Novel Role for Glutathione S-Tranferase π: Regulator of Protein S- Glutathionylation Following Oxidative and Nitrosative Stress
نویسندگان
چکیده
Danyelle M. Townsend, Yefim Manevich, Lin He, Steven Hutchens, Christopher J. Pazoles, Kenneth D. Tew Departments of Pharmaceutical and Biomedical Sciences, Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, 96 Johnathan Lucas St. P.O., Charleston, SC 29425 4 Novelos Inc., One Gateway Ctr, Newton, MA 02458. Running head: GSTπ catalyzes S-glutathionylation Address correspondence to: Kenneth D. Tew, Ph.D., DSc, Medical University of South Carolina, 96 Johnathan Lucas St. P.O., Charleston, SC 29425: [email protected]
منابع مشابه
Novel role for glutathione S-transferase pi. Regulator of protein S-Glutathionylation following oxidative and nitrosative stress.
Glutathione S-transferase Pi (GSTpi) is a marker protein in many cancers and high levels are linked to drug resistance, even when the selecting drug is not a substrate. S-Glutathionylation of proteins is critical to cellular stress response, but characteristics of the forward reaction are not known. Our results show that GSTpi potentiates S-glutathionylation reactions following oxidative and ni...
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